Scientific Related Articles
Related Scientific Articles
Transcranial direct current stimulation (tDCS) has beneficial effects on liver lipid accumulation and hepatic inflammatory parameter – Click Here
Regulation of liver regeneration by growth factors and …
www.ncbi.nlm.nih.gov/…
National Center for Biotechnology Information
by F Böhm – 2010 – Cited by 74 – Related articles
Figure 1. The different cell types of the liver and liver regeneration after ….. factor showed delayed liver regeneration due to insulin/IGF–1 resistance that was …
Am. J. Physiol. Gastrointest. Liver Physiol.
Am J Physiol Gastrointest Liver Physiol 2016 Mar 3:ajpgi.00056.2016. Epub 2016 Mar 3.
Laurie D DeLeve, Xiangdong Wang, Lei Wang
In liver injury, recruitment of bone marrow progenitors of liver sinusoidal endothelial cells (now named sprocs) is necessary for normal liver regeneration. Hepatic VEGF is a central regulator of the recruitment process. Here we examine whether stromal cell derived factor-1 (sdf-1 or CXCL-12) acts downstream from VEGF to mediate recruitment of bone marrow sprocs, what the sdf-1 receptor type (CXCR4 or CXCR7) is on sprocs, and whether sdf-1 signaling is required for normal liver regeneration.
Studies were performed in the rat partial hepatectomy model. Tracking studies of bone marrow sprocs were performed in wild type Lewis rats that had undergone bone marrow transplantation from transgenic EGFP+ Lewis rats. Knockdown studies were performed using anti-sense oligonucleotides.
Expression of sdf-1 doubles in liver and in LSECs after partial hepatectomy. The upregulation of sdf-1 expression increases proliferation of sprocs in the bone marrow, mobilization of CXCR7+ bone marrow sprocs to the circulation, and engraftment of CXCR7+ bone marrow sprocs in the liver, and promotes liver regeneration. Knockdown of hepatic VEGF with anti-sense oligonucleotides decreases hepatic sdf-1 expression and plasma sdf-1 levels. When the effect of VEGF knockdown on sdf-1 is offset by infusion of sdf-1, VEGF knockdown-induced impairment of BM sproc recruitment after partial hepatectomy is completely attenuated and liver regeneration is normalized.
These data demonstrate that the VEGF-sdf-1 pathway regulates recruitment of CXCR7+ bone marrow sprocs to the hepatic sinusoid after partial hepatectomy and is required for normal liver regeneration.
Affiliation
University of Southern California Keck School of Medicine.
[PDF]
Signals and Cells Involved in Regulating Liver Regeneration
www.mdpi.com/2073-4409/1/4/1261/pdf
MDPI
by LI Kang – 2012 – Cited by 30 – Related articles
Dec 13, 2012 – Keywords: liver regeneration; hepatocyte; hepatocyte growth factor; epidermal growth factor … IGF1), as well as other functions. The ability of ..
Hepatocyte proliferation during liver regeneration is …
www.fasebj.org/content/20/6/773.full
The FASEB Journal
by C Desbois-Mouthon – 2006 – Cited by 82 – Related articles
Feb 16, 2006 – To test whether IGF-1R regulates liver regeneration, we performed partial hepatectomy in liver-specific IGF type 1 receptor knockout …
HGF and SDF-1-mediated mobilization of CD133+ BMSC …
www.ncbi.nlm.nih.gov/…
National Center for Biotechnology Information
by N Lehwald – 2014 – Cited by 12 – Related articles
May 23, 2013 – 1. Liver Int. 2014 Jan;34(1):89-101. doi: 10.1111/liv.12195. … of CD133+ BMSC for hepatic regeneration following extensive liver resection.
SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury …
www.hindawi.com/journals/sci/aa/960387/
by NB Hao – Related articles
Mar 6, 2015 – SDF–1/CXCR4 Axis Promotes MSCs to RepairLiver Injury Partially … been a popular topic in regenerativemedicine and have generated a …
involvement of sdf-1 in stem cell-aided liver regeneration
ufdcimages.uflib.ufl.edu/UF/E0/01/36/86/00001/zheng_d.pdf
INVOLVEMENT OF SDF–1 IN STEM CELL-AIDED LIVER REGENERATION. By. DONGHANG ZHENG. A DISSERTATION PRESENTED TO THE GRADUATE …
A single intraportal administration of follistatin … – NCBI
www.ncbi.nlm.nih.gov/…
National Center for Biotechnology Information
by K Kogure – 1995 – Cited by 98 – Related articles
A single intraportal administration of follistatin accelerates liver regeneration in partially hepatectomized rats. Kogure K(1), Omata W, Kanzaki M, Zhang YQ, …
Activin or follistatin: which is more beneficial to support liver …
www.ncbi.nlm.nih.gov/…/1… National Center for Biotechnology Information
by D Endo – 2006 – Cited by 37 – Related articles
Endocr J. 2006 Feb;53(1):73-8. Activin or follistatin: which is more beneficial to support liver regeneration after massive hepatectomy? Endo D(1), Maku-Uchi M, …
Reversibility of liver fibrosis | Fibrogenesis & Tissue Repair …
fibrogenesis.biomedcentral.com/articles/10.1186/1755-1536-5-S1-S26
by A Pellicoro – 2012 – Cited by 52 – Related articles
Jun 6, 2012 – We have shown that elastin turnover in liver injury and fibrosis is regulated … step in the interlinked processes of tissue injury and regeneration.
VEGF is Important for Early Liver Regeneration After Partial …
www.sciencedirect.com/science/…/S0022480406003933
ScienceDirect
by M Bockhorn – 2007 – Cited by 71 – Related articles
VEGF plays an important role in liver regeneration and this may be due in part through its effects on neovascularization. Whether it may, when given …
Roles of vascular endothelial growth factor and endothelial …
link.springer.com/…/10.1007%2Fs00595-… Springer Science+Business Media
by D Yoshida – 2011 – Cited by 13 – Related articles
Liver regeneration and SEC proliferation were evaluated. The protein expression of VEGF and eNOS was examined by a Western blot analysis. The rats were …
Signals and Cells Involved in Regulating Liver Regeneration
www.mdpi.com/2073-4409/1/4/1261/pdf
Bone marrow stem cells and liver disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1942133/
Summary:
- SDF-1/CXCR4 signaling central to BMSC homing to liver
- BMSCs support liver repair through the delivery of growth factors that promote liver regeneration, fibrosis resolution or new blood vessel formation
-
- Of specific interest, BMSCs upregulate HGF which may play a role in diminishing fibrosis
Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis
http://www.ncbi.nlm.nih.gov/pubmed/15793283/
Effects of transcutaneous electrical stimulation of lower limb … – NCBI
Apr 5, 2016 – Effects of transcutaneous electrical stimulation of lower limb muscles on experimental fatty liver. El-Kafoury BM(1), Seif AA(2), El-Aziz Abd …